diff --git a/.cirrus.yml b/.cirrus.yml
index 93f94af73..750c3e863 100644
--- a/.cirrus.yml
+++ b/.cirrus.yml
@@ -138,7 +138,7 @@ task:
   name: 'macOS 10.14 native [GOAL: install] [GUI] [no depends]'
   brew_install_script:
     - brew update
-    - brew install boost libevent berkeley-db4 qt@5 miniupnpc ccache zeromq qrencode sqlite libtool automake pkg-config gnu-getopt
+    - brew install boost libevent qt@5 miniupnpc ccache zeromq qrencode sqlite libtool automake pkg-config gnu-getopt
   << : *GLOBAL_TASK_TEMPLATE
   osx_instance:
     # Use latest image, but hardcode version to avoid silent upgrades (and breaks)
diff --git a/ci/test/00_setup_env_mac_host.sh b/ci/test/00_setup_env_mac_host.sh
index a710d983e..1ca92535c 100644
--- a/ci/test/00_setup_env_mac_host.sh
+++ b/ci/test/00_setup_env_mac_host.sh
@@ -9,7 +9,8 @@ export LC_ALL=C.UTF-8
 export HOST=x86_64-apple-darwin16
 export PIP_PACKAGES="zmq"
 export GOAL="install"
-export BITCOIN_CONFIG="--with-gui --enable-reduce-exports --with-boost-process"
+export BDB_PREFIX="${BASE_ROOT_DIR}/db5"
+export BITCOIN_CONFIG="--with-gui --enable-reduce-exports --with-boost-process BDB_LIBS='-L${BDB_PREFIX}/lib -ldb_cxx-5.3' BDB_CFLAGS='-I${BDB_PREFIX}/include'"
 export CI_OS_NAME="macos"
 export NO_DEPENDS=1
 export OSX_SDK=""
diff --git a/ci/test/05_before_script.sh b/ci/test/05_before_script.sh
index 5d0034be1..89ecb4ac7 100755
--- a/ci/test/05_before_script.sh
+++ b/ci/test/05_before_script.sh
@@ -31,6 +31,11 @@ if [[ ${USE_MEMORY_SANITIZER} == "true" ]]; then
   DOCKER_EXEC "contrib/install_db5.sh \$(pwd) --enable-umrw CC=clang CXX=clang++ CFLAGS='${MSAN_FLAGS}' CXXFLAGS='${MSAN_AND_LIBCXX_FLAGS}'"
 fi
 
+if [[ $HOST = *-apple-darwin16 ]]; then
+  # Use BDB compiled using install_db5.sh script as Brew does not supply BDB 5.3
+  DOCKER_EXEC "contrib/install_db5.sh \$BASE_ROOT_DIR --enable-posixmutexes"
+fi
+
 if [ -n "$XCODE_VERSION" ] && [ -f "$OSX_SDK_PATH" ]; then
   DOCKER_EXEC tar -C "${DEPENDS_DIR}/SDKs" -xf "$OSX_SDK_PATH"
 fi