diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index 3670fcec9fd..011ba0defce 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -99,10 +99,10 @@ chain for " target " development."))
 
 (define* (make-bitcoin-cross-toolchain target
                                        #:key
-                                       (base-gcc-for-libc linux-base-gcc)
+                                       (base-gcc-for-libc (gcc-libgcc-patches linux-base-gcc))
                                        (base-kernel-headers base-linux-kernel-headers)
                                        (base-libc glibc-2.31)
-                                       (base-gcc linux-base-gcc))
+                                       (base-gcc (gcc-libgcc-patches linux-base-gcc)))
   "Convenience wrapper around MAKE-CROSS-TOOLCHAIN with default values
 desirable for building Bitcoin Core release binaries."
   (make-cross-toolchain target
@@ -111,7 +111,7 @@ desirable for building Bitcoin Core release binaries."
                         base-libc
                         base-gcc))
 
-(define (gcc-mingw-patches gcc)
+(define (gcc-libgcc-patches gcc)
   (package-with-extra-patches gcc
     (search-our-patches "gcc-remap-guix-store.patch")))
 
@@ -128,10 +128,10 @@ desirable for building Bitcoin Core release binaries."
   (let* ((xbinutils (binutils-mingw-patches (cross-binutils target)))
          (machine (substring target 0 (string-index target #\-)))
          (pthreads-xlibc (winpthreads-patches (make-mingw-w64 machine
-                                         #:xgcc (cross-gcc target #:xgcc (gcc-mingw-patches base-gcc))
+                                         #:xgcc (cross-gcc target #:xgcc (gcc-libgcc-patches base-gcc))
                                          #:with-winpthreads? #t)))
          (pthreads-xgcc (cross-gcc target
-                                    #:xgcc (gcc-mingw-patches mingw-w64-base-gcc)
+                                    #:xgcc (gcc-libgcc-patches mingw-w64-base-gcc)
                                     #:xbinutils xbinutils
                                     #:libc pthreads-xlibc)))
     ;; Define a meta-package that propagates the resulting XBINUTILS, XLIBC, and
diff --git a/contrib/guix/patches/gcc-remap-guix-store.patch b/contrib/guix/patches/gcc-remap-guix-store.patch
index a8b41d485b0..4144bcd8cd1 100644
--- a/contrib/guix/patches/gcc-remap-guix-store.patch
+++ b/contrib/guix/patches/gcc-remap-guix-store.patch
@@ -1,4 +1,4 @@
-Without ffile-prefix-map, the debug symbols will contain paths for the
+Without -ffile-prefix-map, the debug symbols will contain paths for the
 guix store which will include the hashes of each package. However, the
 hash for the same package will differ when on different architectures.
 In order to be reproducible regardless of the architecture used to build
@@ -6,7 +6,7 @@ the package, map all guix store prefixes to something fixed, e.g. /usr.
 
 --- a/libgcc/Makefile.in
 +++ b/libgcc/Makefile.in
-@@ -854,7 +854,7 @@ endif
+@@ -857,7 +857,7 @@ endif
  # libgcc_eh.a, only LIB2ADDEH matters.  If we do, only LIB2ADDEHSTATIC and
  # LIB2ADDEHSHARED matter.  (Usually all three are identical.)
  
@@ -15,6 +15,15 @@ the package, map all guix store prefixes to something fixed, e.g. /usr.
  
  ifeq ($(enable_shared),yes)
  
+@@ -880,7 +880,7 @@ endif
+ # Build LIBUNWIND. Use -fno-exceptions so that the unwind library does
+ # not generate calls to __gcc_personality_v0.
+ 
+-c_flags := -fno-exceptions
++c_flags := -fno-exceptions $(shell find /gnu/store -maxdepth 1 -mindepth 1 -type d -exec echo -n " -ffile-prefix-map={}=/usr" \;)
+ 
+ libunwind-objects += $(addsuffix $(objext),$(basename $(notdir $(LIBUNWIND))))
+ 
 -- 
 2.37.0